New research indicates that people who stop using new GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight far faster than those who stop conventional lifestyle plans.
Findings released in a major medical journal shows that while obese people frequently drop about a fifth of their total mass while undergoing treatment, the mass returns at an average rate of nearly a kilo each month upon discontinuation.
"Users using these medications must be aware of the risk of quick rebound weight gain when the therapy concludes," stated expert Dr. Susan Jebb.
That rate of recovery means a reversion to original weight within about one and a half years.
Comparing Therapies
The research, which reviewed dozens of trials involving over 9,000 of patients, contrasted the results of the injectable medications with conventional dieting.
Scientists note that individuals who shed pounds through dieting usually experience a slower weight regain—perhaps 0.1 kg a month—after stopping.
Explaining the Fast Rebound
Nutrition scientists suggest the way of the drugs is key to understanding the accelerated rebound.
The injections copy a natural hormone called GLP-1, which controls feelings of fullness.
"Sustained high doses of the hormone levels far above than the body's typical production could lead to the body to produce less of its own natural hormone, and could reduce sensitivity to its actions," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this medication leads to appetite is uncontrolled, making binge eating a significant risk."
An Ongoing Disease?
Medical guidelines advise the injections for individuals with obesity-related medical conditions, alongside prescribed lifestyle changes.
Professionals contend that, considering the significant potential of relapse, the therapy is often life-long.
This view is reinforced by drug manufacturers, who say that the findings "highlight the chronic nature of obesity," comparing it to managing conditions like diabetes.
User Experiences
People who have come off the jabs describe a sudden resurgence of hunger.
"It felt as if a trigger that goes on and I was suddenly ravenous," recalled an individual.
This challenge is compounded if individuals have not established permanent dietary or behavioural modifications during therapy.
Widespread Use
Figures show that millions of adults in the UK have used these injections in the last 12 months, with demand continuing to grow.
- Adoption is more common among women compared to men.
- The middle-aged age group shows the greatest usage rates.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Finally, experts caution that while these medications are effective tools for shedding pounds, they are not a magic cure and maintained weight loss hinges on ongoing behavioural changes.
